Cargando…

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability is incompletely understood. We here examined how the apolipoprotein M (apoM)-bound sphingosine 1–phosphate (S1P) signaling pathway affects the...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathiesen Janiurek, Mette, Soylu-Kucharz, Rana, Christoffersen, Christina, Kucharz, Krzysztof, Lauritzen, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877292/
https://www.ncbi.nlm.nih.gov/pubmed/31763978
http://dx.doi.org/10.7554/eLife.49405