Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice

AKR1A, an aldo-keto reductase, is involved in the synthesis of ascorbic acid as well as the reduction of a variety of aldehyde compounds. AKR1A(−/−) mice produce considerably less ascorbic acid (about 10%) compared to AKR1A(+/+) mice and require ascorbic acid supplementation in order to breed. To el...

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Detalles Bibliográficos
Autores principales: Kurihara, Kazuki, Homma, Takujiro, Kobayashi, Sho, Shichiri, Mototada, Fujiwara, Hiroki, Fujii, Satoshi, Yamada, Ken-ichi, Nakane, Masaki, Kawamae, Kaneyuki, Fujii, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877411/
https://www.ncbi.nlm.nih.gov/pubmed/31777422
http://dx.doi.org/10.3164/jcbn.19-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877411/
https://www.ncbi.nlm.nih.gov/pubmed/31777422
http://dx.doi.org/10.3164/jcbn.19-41

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