Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil

Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA in October 2018, drug resistant viruses have already been detected fr...

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Detalles Bibliográficos
Autores principales: Yoshino, Ryunosuke, Yasuo, Nobuaki, Sekijima, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877583/
https://www.ncbi.nlm.nih.gov/pubmed/31767949
http://dx.doi.org/10.1038/s41598-019-53945-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877583/
https://www.ncbi.nlm.nih.gov/pubmed/31767949
http://dx.doi.org/10.1038/s41598-019-53945-1

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