PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone

Activation of nuclear-factor-E2-related factor 2 (Nrf2) cascade can alleviate dexamethasone (DEX)-induced oxidative injury and death of human osteoblasts. A recent study has shown that phosphoglycerate kinase 1 (PGK1) inhibition/depletion will lead to Kelch-like ECH-associated protein 1 (Keap1) meth...

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Detalles Bibliográficos
Autores principales: Liang, Jinqian, Zhang, Xiang-yang, Zhen, Yun-Fang, Chen, Chong, Tan, Haining, Hu, Jianhua, Tan, Ming-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877585/
https://www.ncbi.nlm.nih.gov/pubmed/31767834
http://dx.doi.org/10.1038/s41419-019-2112-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877585/
https://www.ncbi.nlm.nih.gov/pubmed/31767834
http://dx.doi.org/10.1038/s41419-019-2112-1

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