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PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone

Activation of nuclear-factor-E2-related factor 2 (Nrf2) cascade can alleviate dexamethasone (DEX)-induced oxidative injury and death of human osteoblasts. A recent study has shown that phosphoglycerate kinase 1 (PGK1) inhibition/depletion will lead to Kelch-like ECH-associated protein 1 (Keap1) meth...

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Detalles Bibliográficos
Autores principales:	Liang, Jinqian, Zhang, Xiang-yang, Zhen, Yun-Fang, Chen, Chong, Tan, Haining, Hu, Jianhua, Tan, Ming-sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877585/ https://www.ncbi.nlm.nih.gov/pubmed/31767834 http://dx.doi.org/10.1038/s41419-019-2112-1

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