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Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages

P2X7 is an ATP-gated ion channel that is highly expressed by leukocytes, such as macrophages. Here, P2X7 has been demonstrated to be involved in the regulation of various cell death pathways; including apoptosis, pyroptosis, necrosis, and autophagy. However, cell death induction via P2X7 is complex...

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Detalles Bibliográficos
Autores principales: Bidula, Stefan, Dhuna, Kshitija, Helliwell, Ray, Stokes, Leanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877589/
https://www.ncbi.nlm.nih.gov/pubmed/31767863
http://dx.doi.org/10.1038/s41419-019-2110-3