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Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
P2X7 is an ATP-gated ion channel that is highly expressed by leukocytes, such as macrophages. Here, P2X7 has been demonstrated to be involved in the regulation of various cell death pathways; including apoptosis, pyroptosis, necrosis, and autophagy. However, cell death induction via P2X7 is complex...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877589/ https://www.ncbi.nlm.nih.gov/pubmed/31767863 http://dx.doi.org/10.1038/s41419-019-2110-3 |