Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

DNA base editors have enabled genome editing without generating DNA double strand breaks. The applications of this technology have been reported in a variety of animal and plant systems, however, their editing specificity in human stem cells has not been studied by unbiased genome-wide analysis. Her...

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Detalles Bibliográficos
Autores principales: McGrath, Erica, Shin, Hyunsu, Zhang, Linyi, Phue, Je-Nie, Wu, Wells W., Shen, Rong-Fong, Jang, Yoon-Young, Revollo, Javier, Ye, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877639/
https://www.ncbi.nlm.nih.gov/pubmed/31767844
http://dx.doi.org/10.1038/s41467-019-13342-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877639/
https://www.ncbi.nlm.nih.gov/pubmed/31767844
http://dx.doi.org/10.1038/s41467-019-13342-8

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