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Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
DNA base editors have enabled genome editing without generating DNA double strand breaks. The applications of this technology have been reported in a variety of animal and plant systems, however, their editing specificity in human stem cells has not been studied by unbiased genome-wide analysis. Her...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877639/ https://www.ncbi.nlm.nih.gov/pubmed/31767844 http://dx.doi.org/10.1038/s41467-019-13342-8 |