D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity

A- and D-ring-modified luotonin-inspired heterocycles have been synthesized and were evaluated for their activity against the viability of four cancer cell lines in vitro, namely, MCF7, HCT116, JURKAT, and NCI-H460. The analysis of results indicated that two of the synthesized derivatives displayed...

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Detalles Bibliográficos
Autores principales: Almansour, Abdulrahman I., Kumar, Raju Suresh, Arumugam, Natarajan, Bianchini, Giulia, Menéndez, J. Carlos, Mohammad, Faruq, Dupadahalli, Kotresha, Altaf, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877907/
https://www.ncbi.nlm.nih.gov/pubmed/31815127
http://dx.doi.org/10.1155/2019/2514524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877907/
https://www.ncbi.nlm.nih.gov/pubmed/31815127
http://dx.doi.org/10.1155/2019/2514524

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