MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through interacting...

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Detalles Bibliográficos
Autores principales: Bian, Lei, Meng, Yiling, Zhang, Meichao, Li, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878665/
https://www.ncbi.nlm.nih.gov/pubmed/31767017
http://dx.doi.org/10.1186/s12943-019-1100-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878665/
https://www.ncbi.nlm.nih.gov/pubmed/31767017
http://dx.doi.org/10.1186/s12943-019-1100-5

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