Cargando…

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through interacting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bian, Lei, Meng, Yiling, Zhang, Meichao, Li, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878665/ https://www.ncbi.nlm.nih.gov/pubmed/31767017 http://dx.doi.org/10.1186/s12943-019-1100-5

Ejemplares similares

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
por: Situ, Yiling, et al.
Publicado: (2019)

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling
por: Henrich, Sarah Marie, et al.
Publicado: (2017)

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
por: Spycher, Christoph, et al.
Publicado: (2008)

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
por: Rahman, Samiur, et al.
Publicado: (2020)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
por: Taylor, Elaine M., et al.
Publicado: (2010)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
por: Kamisugi, Yasuko, et al.
Publicado: (2012)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
por: Kim, Hyunsup, et al.
Publicado: (2022)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel
por: Garner, Kristen M, et al.
Publicado: (2011)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
por: Schuetz, Johanna M, et al.
Publicado: (2009)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells
por: McPherson, Matthew T., et al.
Publicado: (2020)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
por: Franchitto, Annapaola, et al.
Publicado: (2002)

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer
por: Brandt, Simone, et al.
Publicado: (2017)

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
por: Ho, Vincent, et al.
Publicado: (2018)

Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
por: Belmonte-Fernández, Alejandro, et al.
Publicado: (2022)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
por: Chang, Emily Yun-Chia, et al.
Publicado: (2019)

DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii
por: Delmas, Stéphane, et al.
Publicado: (2013)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
por: Lee, Ji-Hoon, et al.
Publicado: (2013)

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
por: Lee, Joon, et al.
Publicado: (2013)

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein
por: Zhou, Hui, et al.
Publicado: (2017)

The Mre11-Rad50-Xrs2 Complex Is Required for Yeast DNA Postreplication Repair
por: Ball, Lindsay G., et al.
Publicado: (2014)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links
por: Pasadi, Sanjeev, et al.
Publicado: (2020)

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
por: Kim, Hyunsup, et al.
Publicado: (2021)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia
por: Mosor, Maria, et al.
Publicado: (2013)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex
por: Otahalova, Barbora, et al.
Publicado: (2023)

Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
por: Friis, Ida, et al.
Publicado: (2018)

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex
por: Canny, Marella D, et al.
Publicado: (2022)

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
por: Möckel, Carolin, et al.
Publicado: (2012)

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2013)

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex
por: Lim, Chew Theng, et al.
Publicado: (2015)

Mre11-Rad50 Promotes Rapid Repair of DNA Damage in the Polyploid Archaeon Haloferax volcanii by Restraining Homologous Recombination
por: Delmas, Stéphane, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_v3dls2lbu36nfcgb92p5guoc72