DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

BACKGROUND: The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor recurrence and poor prognosis of hepatocellular carcinomas (HCC). DNA methyltransferase (DNMT) family is closely lin...

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Detalles Bibliográficos
Autores principales: Lai, Ssu-Chuan, Su, Yu-Ting, Chi, Ching-Chi, Kuo, Yung-Che, Lee, Kam-Fai, Wu, Yu-Chih, Lan, Pei-Chi, Yang, Muh-Hwa, Chang, Te-Sheng, Huang, Yen-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878666/
https://www.ncbi.nlm.nih.gov/pubmed/31771617
http://dx.doi.org/10.1186/s13046-019-1442-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878666/
https://www.ncbi.nlm.nih.gov/pubmed/31771617
http://dx.doi.org/10.1186/s13046-019-1442-2

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