DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions

The RNA binding protein DAZL is essential for gametogenesis, but its direct in vivo functions, RNA targets, and the molecular basis for germ cell loss in Dazl-null mice are unknown. Here, we mapped transcriptome-wide DAZL-RNA interactions in vivo, revealing DAZL binding to thousands of mRNAs via pol...

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Detalles Bibliográficos
Autores principales: Zagore, Leah L., Sweet, Thomas J., Hannigan, Molly M., Weyn-Vanhentenryck, Sebastien M., Jobava, Raul, Hatzoglou, Maria, Zhang, Chaolin, Licatalosi, Donny D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878787/
https://www.ncbi.nlm.nih.gov/pubmed/30380414
http://dx.doi.org/10.1016/j.celrep.2018.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878787/
https://www.ncbi.nlm.nih.gov/pubmed/30380414
http://dx.doi.org/10.1016/j.celrep.2018.10.012

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