Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen

Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompa...

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Detalles Bibliográficos
Autores principales: Low, Lionel, Goh, Angeline, Koh, Joanna, Lim, Samantha, Wang, Cheng-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879612/
https://www.ncbi.nlm.nih.gov/pubmed/31772160
http://dx.doi.org/10.1038/s41467-019-13305-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879612/
https://www.ncbi.nlm.nih.gov/pubmed/31772160
http://dx.doi.org/10.1038/s41467-019-13305-z

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