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Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen
Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879612/ https://www.ncbi.nlm.nih.gov/pubmed/31772160 http://dx.doi.org/10.1038/s41467-019-13305-z |