A framework for identification of on- and off-target transcriptional responses to drug treatment

Owing to safety concerns or insufficient efficacy, few drug candidates are approved for marketing. Drugs already on the market may be withdrawn due to adverse effects (AEs) discovered after market introduction. Comprehensively investigating the on-/off-target effects of drugs can help expose AEs dur...

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Detalles Bibliográficos
Autores principales: Huang, Yi, Furuno, Masaaki, Arakawa, Takahiro, Takizawa, Satoshi, de Hoon, Michiel, Suzuki, Harukazu, Arner, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879629/
https://www.ncbi.nlm.nih.gov/pubmed/31772269
http://dx.doi.org/10.1038/s41598-019-54180-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879629/
https://www.ncbi.nlm.nih.gov/pubmed/31772269
http://dx.doi.org/10.1038/s41598-019-54180-4

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