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Detecting Weak Signals by Combining Small P-Values in Genetic Association Studies

We approach the problem of combining top-ranking association statistics or P-values from a new perspective which leads to a remarkably simple and powerful method. Statistical methods, such as the rank truncated product (RTP), have been developed for combining top-ranking associations, and this gener...

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Detalles Bibliográficos
Autores principales: Vsevolozhskaya, Olga A., Hu, Fengjiao, Zaykin, Dmitri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879667/
https://www.ncbi.nlm.nih.gov/pubmed/31824555
http://dx.doi.org/10.3389/fgene.2019.01051