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Detecting Weak Signals by Combining Small P-Values in Genetic Association Studies
We approach the problem of combining top-ranking association statistics or P-values from a new perspective which leads to a remarkably simple and powerful method. Statistical methods, such as the rank truncated product (RTP), have been developed for combining top-ranking associations, and this gener...
Autores principales: | Vsevolozhskaya, Olga A., Hu, Fengjiao, Zaykin, Dmitri V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879667/ https://www.ncbi.nlm.nih.gov/pubmed/31824555 http://dx.doi.org/10.3389/fgene.2019.01051 |
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