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Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E(2) synthesis in the brain and their behavioral relevance

Inflammation in the brain and periphery has been associated with stress-related pathology of mental illness. We have shown that prostaglandin (PG) E(2), an arachidonic acid-derived lipid mediator, and innate immune receptors Toll-like receptor (TLR) 2/4 are crucial for repeated stress-induced behavi...

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Detalles Bibliográficos
Autores principales: Nie, Xiang, Kitaoka, Shiho, Shinohara, Masakazu, Kakizuka, Akira, Narumiya, Shuh, Furuyashiki, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879743/
https://www.ncbi.nlm.nih.gov/pubmed/31772309
http://dx.doi.org/10.1038/s41598-019-54082-5