Cyclophilin A protects HIV-1 from restriction by human TRIM5α

The HIV-1 capsid (CA) protein lattice encases viral genomic RNA and regulates steps essential to target cell invasion(1). Cyclophilin A (CypA) has interacted with the CA of lentiviruses related to HIV-1 for millions of years(2–7). Disruption of the CA-CypA interaction decreases HIV-1 infectivity in...

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Detalles Bibliográficos
Autores principales: Kim, Kyusik, Dauphin, Ann, Komurlu, Sevnur, McCauley, Sean M., Yurkovetskiy, Leonid A., Carbone, Claudia, Diehl, William E., Strambio-De-Castillia, Caterina, Campbell, Edward M., Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879858/
https://www.ncbi.nlm.nih.gov/pubmed/31636416
http://dx.doi.org/10.1038/s41564-019-0592-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879858/
https://www.ncbi.nlm.nih.gov/pubmed/31636416
http://dx.doi.org/10.1038/s41564-019-0592-5

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