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Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity

Posttraumatic stress disorder (PTSD) is associated with neuroendocrine alterations and metabolic abnormalities; however, how metabolism is affected by neuroendocrine disturbances is unclear. The data from combat-exposed veterans with PTSD show increased glycolysis to lactate flux, reduced TCA cycle...

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Detalles Bibliográficos
Autores principales: Somvanshi, Pramod R., Mellon, Synthia H., Flory, Janine D., Abu-Amara, Duna, Wolkowitz, Owen M., Yehuda, Rachel, Jett, Marti, Hood, Leroy, Marmar, Charles, Doyle, Francis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879860/
https://www.ncbi.nlm.nih.gov/pubmed/31322414
http://dx.doi.org/10.1152/ajpendo.00065.2019