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Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants

INTRODUCTION: The role of TOMM40-APOE 19q13.3 region variants is well documented in Alzheimer's disease (AD) but remains contentious in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). METHODS: We dissected genetic profiles within the TOMM40-APOE region in 451 indivi...

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Detalles Bibliográficos
Autores principales: Prokopenko, Inga, Miyakawa, Gentaro, Zheng, Bang, Heikkinen, Jani, Petrova Quayle, Daniela, Udeh-Momoh, Chinedu, Claringbould, Annique, Neumann, Juliane, Haytural, Hazal, Kaakinen, Marika A., Loizidou, Elena, Meissner, Esther, Bertram, Lars, Gveric, Djordje O., Gentleman, Steve M., Attems, Johannes, Perneczky, Robert, Arzberger, Thomas, Muglia, Pierandrea, Lill, Christina M., Parkkinen, Laura, Middleton, Lefkos T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880091/
https://www.ncbi.nlm.nih.gov/pubmed/31788537
http://dx.doi.org/10.1016/j.trci.2019.08.005