Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

This study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to construct a PK/PD model to predict serum urate (SUA) levels after dotinurad administration in healthy men. PK/PD model was constructed using single‐dose study data...

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Detalles Bibliográficos
Autores principales: Motoki, Keisuke, Igarashi, Takako, Omura, Koichi, Nakatani, Hiroshi, Iwanaga, Takashi, Tamai, Ikumi, Ohashi, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880184/
https://www.ncbi.nlm.nih.gov/pubmed/31788318
http://dx.doi.org/10.1002/prp2.533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880184/
https://www.ncbi.nlm.nih.gov/pubmed/31788318
http://dx.doi.org/10.1002/prp2.533

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