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Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone
BACKGROUND: Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of articular cartilage. METHODS: Wnt/β-catenin signaling activity wa...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880374/ https://www.ncbi.nlm.nih.gov/pubmed/31771658 http://dx.doi.org/10.1186/s13075-019-2041-5 |