Cargando…

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

BACKGROUND: Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of articular cartilage. METHODS: Wnt/β-catenin signaling activity wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xuan, Fengjun, Yano, Fumiko, Mori, Daisuke, Chijimatsu, Ryota, Maenohara, Yuji, Nakamoto, Hideki, Mori, Yoshifumi, Makii, Yuma, Oichi, Takeshi, Taketo, Makoto Mark, Hojo, Hironori, Ohba, Shinsuke, Chung, Ung-il, Tanaka, Sakae, Saito, Taku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880374/ https://www.ncbi.nlm.nih.gov/pubmed/31771658 http://dx.doi.org/10.1186/s13075-019-2041-5

Ejemplares similares

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development
por: Nagata, Kosei, et al.
Publicado: (2022)

Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation
por: Saito, Taku, et al.
Publicado: (2013)

Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation
por: Yano, Fumiko, et al.
Publicado: (2019)

Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds
por: Kawata, Manabu, et al.
Publicado: (2019)

Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
por: Higuchi, Junya, et al.
Publicado: (2020)

Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion
por: Murahashi, Yasutaka, et al.
Publicado: (2019)

Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis
por: Murahashi, Yasutaka, et al.
Publicado: (2018)

Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling
por: Okada, Keita, et al.
Publicado: (2020)

Different regulation of limb development by p63 transcript variants
por: Kawata, Manabu, et al.
Publicado: (2017)

Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering
por: Hamamoto, Shuichi, et al.
Publicado: (2020)

Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology
por: Fujii, Yasuyuki, et al.
Publicado: (2018)

Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis
por: Karamchedu, Naga Padmini, et al.
Publicado: (2016)

A report of the 17th congress of the Japanese Society for Regenerative Medicine
por: Ohba, Shinsuke, et al.
Publicado: (2018)

Identification of the gene-regulatory landscape in skeletal development and potential links to skeletal regeneration
por: Hojo, Hironori, et al.
Publicado: (2017)

Signaling pathways regulating the specification and differentiation of the osteoblast lineage
por: Hojo, Hironori, et al.
Publicado: (2015)

RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification
por: Tachibana, Naohiro, et al.
Publicado: (2022)

Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation
por: Yano, Fumiko, et al.
Publicado: (2022)

The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells
por: Kushioka, Junichi, et al.
Publicado: (2020)

Understanding paraxial mesoderm development and sclerotome specification for skeletal repair
por: Tani, Shoichiro, et al.
Publicado: (2020)

Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints
por: Ai, Minrong, et al.
Publicado: (2015)

Tenomodulin Expression in the Periodontal Ligament Enhances Cellular Adhesion
por: Komiyama, Yuske, et al.
Publicado: (2013)

Automatic Detection of Medial and Lateral Compartments from Histological Sections of Mouse Knee Joints Using the Single-Shot Multibox Detector Algorithm
por: Mori, Yoshifumi, et al.
Publicado: (2022)

The Progress of Stem Cell Technology for Skeletal Regeneration
por: Tani, Shoichiro, et al.
Publicado: (2021)

Insights into Gene Regulatory Networks in Chondrocytes
por: Hojo, Hironori, et al.
Publicado: (2019)

Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases
por: Hojo, Hironori, et al.
Publicado: (2022)

Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases
por: Hojo, Hironori, et al.
Publicado: (2023)

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
por: Chang, Song Ho, et al.
Publicado: (2019)

Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage
por: Ni, Guo-Xin, et al.
Publicado: (2012)

Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage
por: Reesink, Heidi L., et al.
Publicado: (2016)

Gli1 Haploinsufficiency Leads to Decreased Bone Mass with an Uncoupling of Bone Metabolism in Adult Mice
por: Kitaura, Yoshiaki, et al.
Publicado: (2014)

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
por: Kobayashi, Hiroshi, et al.
Publicado: (2016)

Identification of SCAN Domain Zinc-Finger Gene ZNF449 as a Novel Factor of Chondrogenesis
por: Okada, Keita, et al.
Publicado: (2014)

Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions
por: Zujur, Denise, et al.
Publicado: (2017)

The superficial zone of articular cartilage
por: Saito, Taku
Publicado: (2022)

Single-cell RNA sequencing unravels heterogeneity of skeletal progenitors and cell–cell interactions underlying the bone repair process
por: Nakayama, Mika, et al.
Publicado: (2022)

Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid
por: Bonnevie, Edward D., et al.
Publicado: (2015)

Stepwise Differentiation of Pluripotent Stem Cells into Osteoblasts Using Four Small Molecules under Serum-free and Feeder-free Conditions
por: Kanke, Kosuke, et al.
Publicado: (2014)

Lubricin Protects the Temporomandibular Joint Surfaces from Degeneration
por: Hill, Adele, et al.
Publicado: (2014)

The Effect of Lubricin on the Gliding Resistance of Mouse Intrasynovial Tendon
por: Hayashi, Masanori, et al.
Publicado: (2013)

Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints
por: Zhang, Dafang, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qllnvd339bna8lo34qiu4015q0