IL-17 inhibits CXCL9/10-mediated recruitment of CD8(+) cytotoxic T cells and regulatory T cells to colorectal tumors

BACKGROUND: The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear. IL-17 also dampens Th1-armed anti-tumor immunity, in part by attracting my...

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Detalles Bibliográficos
Autores principales: Chen, Ju, Ye, Xiaoyang, Pitmon, Elise, Lu, Mengqian, Wan, Jun, Jellison, Evan R., Adler, Adam J., Vella, Anthony T., Wang, Kepeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880503/
https://www.ncbi.nlm.nih.gov/pubmed/31775909
http://dx.doi.org/10.1186/s40425-019-0757-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880503/
https://www.ncbi.nlm.nih.gov/pubmed/31775909
http://dx.doi.org/10.1186/s40425-019-0757-z

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