Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis

BACKGROUND: Cathepsin L and some other cathepsins have been implicated in the development of obesity in humans and mice. The functional inactivation of the proteases reduces fat accumulation during mammalian adipocyte differentiation. However, beyond degrading extracellular matrix protein fibronecti...

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Detalles Bibliográficos
Autores principales: Lin, Yan, Bao, Bin, Yin, Hao, Wang, Xin, Feng, Airong, Zhao, Lin, Nie, Xianqi, Yang, Nan, Shi, Guo-Ping, Liu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880508/
https://www.ncbi.nlm.nih.gov/pubmed/31771567
http://dx.doi.org/10.1186/s12915-019-0719-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880508/
https://www.ncbi.nlm.nih.gov/pubmed/31771567
http://dx.doi.org/10.1186/s12915-019-0719-4

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