Cargando…

Validation and characterisation of a DNA methylation alcohol biomarker across the life course

BACKGROUND: Recently, an alcohol predictor was developed using DNA methylation at 144 CpG sites (DNAm-Alc) as a biomarker for improved clinical or epidemiologic assessment of alcohol-related ill health. We validate the performance and characterise the drivers of this DNAm-Alc for the first time in i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yousefi, Paul Darius, Richmond, Rebecca, Langdon, Ryan, Ness, Andrew, Liu, Chunyu, Levy, Daniel, Relton, Caroline, Suderman, Matthew, Zuccolo, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880546/ https://www.ncbi.nlm.nih.gov/pubmed/31775873 http://dx.doi.org/10.1186/s13148-019-0753-7

Ejemplares similares

DNA methylation as a marker for prenatal smoke exposure in adults
por: Richmond, Rebecca C, et al.
Publicado: (2018)

Epigenetic modelling of former, current and never smokers
por: Langdon, Ryan J., et al.
Publicado: (2021)

Assessment of Offspring DNA Methylation across the Lifecourse Associated with Prenatal Maternal Smoking Using Bayesian Mixture Modelling
por: de Vocht, Frank, et al.
Publicado: (2015)

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort
por: de Vocht, Frank, et al.
Publicado: (2019)

Investigating the DNA methylation profile of e-cigarette use
por: Richmond, Rebecca C., et al.
Publicado: (2021)

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer
por: Beynon, Rhona A., et al.
Publicado: (2022)

Systematic identification of genetic influences on methylation across the human life course
por: Gaunt, Tom R., et al.
Publicado: (2016)

Chromosome 18 Loss of Heterozygosity in Small Intestinal Neuroendocrine Tumours: Multi-Omic and Tumour Composition Analyses
por: Waterfield, Scott, et al.
Publicado: (2023)

Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data
por: Marioni, Riccardo E, et al.
Publicado: (2019)

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer
por: Langdon, Ryan, et al.
Publicado: (2020)

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
por: Reed, Zoe E., et al.
Publicado: (2020)

Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
por: Sharp, Gemma C, et al.
Publicado: (2018)

Meffil: efficient normalization and analysis of very large DNA methylation datasets
por: Min, J L, et al.
Publicado: (2018)

Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer
por: Langdon, Ryan J., et al.
Publicado: (2020)

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study
por: Tang, Rosalind, et al.
Publicado: (2020)

Epigenome-wide association study of asthma and wheeze in childhood and adolescence
por: Arathimos, Ryan, et al.
Publicado: (2017)

A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57
por: Irwin, Rachelle E., et al.
Publicado: (2019)

Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children
por: Sharp, Gemma C, et al.
Publicado: (2015)

DNA methylation signature of passive smoke exposure is less pronounced than active smoking: The Understanding Society study
por: Hulls, Paige M., et al.
Publicado: (2020)

Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
por: Elliott, Hannah R., et al.
Publicado: (2022)

Impact of sex hormone-binding globulin on the human phenome
por: Arathimos, Ryan, et al.
Publicado: (2020)

Do Mass Spectrometry-Derived Metabolomics Improve the Prediction of Pregnancy-Related Disorders? Findings from a UK Birth Cohort with Independent Validation
por: McBride, Nancy, et al.
Publicado: (2021)

Alcohol Intake and Hypertensive Disorders of Pregnancy: A Negative Control Analysis in the ALSPAC Cohort
por: Martin, Florence Z., et al.
Publicado: (2022)

Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences
por: Roberts, Susanna, et al.
Publicado: (2019)

The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)
por: Richmond, Rebecca C, et al.
Publicado: (2018)

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
por: Richmond, Rebecca C., et al.
Publicado: (2015)

Alcohol consumption and epigenetic age acceleration across human adulthood
por: Wang, Mengyao, et al.
Publicado: (2023)

DNA methylation from birth to late adolescence and development of multiple-risk behaviours
por: de Vocht, F., et al.
Publicado: (2018)

Longitudinal analysis of DNA methylation associated with birth weight and gestational age
por: Simpkin, Andrew J., et al.
Publicado: (2015)

Methods for Dealing With Missing Covariate Data in Epigenome-Wide Association Studies
por: Mills, Harriet L, et al.
Publicado: (2019)

Alcohol Exposure In Utero and Child Academic Achievement(*)
por: von Hinke Kessler Scholder, Stephanie, et al.
Publicado: (2014)

Childhood adversity and DNA methylation in two population-based cohorts
por: Houtepen, L. C., et al.
Publicado: (2018)

Do nuclear magnetic resonance (NMR)-based metabolomics improve the prediction of pregnancy-related disorders? Findings from a UK birth cohort with independent validation
por: McBride, Nancy, et al.
Publicado: (2020)

Investigating the impact of cigarette smoking behaviours on DNA methylation patterns in adolescence
por: Prince, Claire, et al.
Publicado: (2019)

Association between Breastfeeding and DNA Methylation over the Life Course: Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
por: Hartwig, Fernando Pires, et al.
Publicado: (2020)

Genetic impacts on DNA methylation help elucidate regulatory genomic processes
por: Villicaña, Sergio, et al.
Publicado: (2023)

Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course
por: Hughes, Amanda, et al.
Publicado: (2018)

Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study
por: Nounu, Aayah, et al.
Publicado: (2022)

Prenatal alcohol exposure and childhood balance ability: findings from a UK birth cohort study
por: Humphriss, Rachel, et al.
Publicado: (2013)

DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework
por: Richmond, Rebecca C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fpl6c7kapj8bktgq6n5kdjc21b