Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis

OBJECTIVES: To determine Bruton’s tyrosine kinase (BTK) protein and phosphorylation levels in B cell subsets of granulomatosis with polyangiitis (GPA) patients and to investigate the effect of BTK blockade on in vitro B cell cytokine production, subset distribution and (auto)antibody production. MET...

Descripción completa

Detalles Bibliográficos
Autores principales: von Borstel, Anouk, Abdulahad, Wayel H, Sanders, Jan Stephan, Rip, Jasper, Neys, Stefan F H, Hendriks, Rudi W, Stegeman, Coen A, Heeringa, Peter, Rutgers, Abraham, Corneth, Odilia B J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880857/
https://www.ncbi.nlm.nih.gov/pubmed/31209475
http://dx.doi.org/10.1093/rheumatology/kez205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880857/
https://www.ncbi.nlm.nih.gov/pubmed/31209475
http://dx.doi.org/10.1093/rheumatology/kez205

Ejemplares similares