Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion

Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of the non-homologous end-joining (NHEJ) activity of DNA-PKcs prevented DNA damage-induced expansion of FA pre-leukemic hematopoietic stem cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Chatla, Srinivas, Wilson, Andrew F., Pang, Qishen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881041/
https://www.ncbi.nlm.nih.gov/pubmed/31474030
http://dx.doi.org/10.15283/ijsc19074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881041/
https://www.ncbi.nlm.nih.gov/pubmed/31474030
http://dx.doi.org/10.15283/ijsc19074

Ejemplares similares