Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies

Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it is still unclear whether afflicted families are likely to share a single highly penetrant rare variant, many minimally penetrant common variants, or a combination of the two types of variants. We there...

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Detalles Bibliográficos
Autores principales: Schlafly, Andrew, Pfeiffer, Ruth M., Nagore, Eduardo, Puig, Susana, Calista, Donato, Ghiorzo, Paola, Menin, Chiara, Fargnoli, Maria Concetta, Peris, Ketty, Song, Lei, Zhang, Tongwu, Shi, Jianxin, Landi, Maria Teresa, Sampson, Joshua Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881075/
https://www.ncbi.nlm.nih.gov/pubmed/31730655
http://dx.doi.org/10.1371/journal.pgen.1008490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881075/
https://www.ncbi.nlm.nih.gov/pubmed/31730655
http://dx.doi.org/10.1371/journal.pgen.1008490

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