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Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies
Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it is still unclear whether afflicted families are likely to share a single highly penetrant rare variant, many minimally penetrant common variants, or a combination of the two types of variants. We there...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881075/ https://www.ncbi.nlm.nih.gov/pubmed/31730655 http://dx.doi.org/10.1371/journal.pgen.1008490 |