Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and antidepressant-like effects. Moreover, DOP agonists show reduced adverse effects as compared to μ-opioid receptor (MOP) agonists that are in the spotli...

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Detalles Bibliográficos
Autores principales: Claff, Tobias, Yu, Jing, Blais, Véronique, Patel, Nilkanth, Martin, Charlotte, Wu, Lijie, Han, Gye Won, Holleran, Brian J., Van der Poorten, Olivier, White, Kate L., Hanson, Michael A., Sarret, Philippe, Gendron, Louis, Cherezov, Vadim, Katritch, Vsevolod, Ballet, Steven, Liu, Zhi-Jie, Müller, Christa E., Stevens, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881160/
https://www.ncbi.nlm.nih.gov/pubmed/31807708
http://dx.doi.org/10.1126/sciadv.aax9115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881160/
https://www.ncbi.nlm.nih.gov/pubmed/31807708
http://dx.doi.org/10.1126/sciadv.aax9115

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