Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading

Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin resistance in skeletal muscle. Precisely how mitochondrial dysfunction is initiated and whether it contributes to insulin...

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Detalles Bibliográficos
Autores principales: Nisr, Raid B., Shah, Dinesh S., Ganley, Ian G., Hundal, Harinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881256/
https://www.ncbi.nlm.nih.gov/pubmed/31101940
http://dx.doi.org/10.1007/s00018-019-03148-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881256/
https://www.ncbi.nlm.nih.gov/pubmed/31101940
http://dx.doi.org/10.1007/s00018-019-03148-8

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