Cargando…
Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis
The pathological aggregation of tau characterizes a set of neurodegenerative diseases collectively referred to as tauopathies. Recent studies using cellular and animal models have suggested that tau pathology progresses by trans-cellular propagation. The process of propagation is mediated by certain...
Autores principales: | Tanaka, Yuki, Yamada, Kaoru, Satake, Kyoko, Nishida, Itaru, Heuberger, Matthias, Kuwahara, Tomoki, Iwatsubo, Takeshi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881304/ https://www.ncbi.nlm.nih.gov/pubmed/31824253 http://dx.doi.org/10.3389/fnins.2019.01258 |
Ejemplares similares
-
Inert and seed-competent tau monomers suggest structural origins of aggregation
por: Mirbaha, Hilda, et al.
Publicado: (2018) -
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
por: Soares, Alberto Carpinteiro, et al.
Publicado: (2021) -
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
por: Ishida, Kazuhisa, et al.
Publicado: (2022) -
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
por: Xu, Yin, et al.
Publicado: (2021) -
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
por: Manos, Justine D., et al.
Publicado: (2021)