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Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53
Mutations in one allele of the TP53 gene in cancer early stages are frequently followed by the loss of the remaining wild-type allele (LOH) during tumor progression. However, the clinical impact of TP53 mutations and p53LOH, especially in the context of genotoxic modalities, remains unclear. Using M...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881331/ https://www.ncbi.nlm.nih.gov/pubmed/31799437 http://dx.doi.org/10.1038/s42003-019-0669-y |