Increase in negative charge of (68)Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules

Upregulation of the human epidermal growth factor receptor type 3 (HER3) is a common mechanism to bypass HER-targeted cancer therapy. Affibody-based molecular imaging has the potential for detecting and monitoring HER3 expression during treatment. In this study, we compared the imaging properties of...

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Detalles Bibliográficos
Autores principales: Rinne, Sara S., Dahlsson Leitao, Charles, Gentry, Joshua, Mitran, Bogdan, Abouzayed, Ayman, Tolmachev, Vladimir, Ståhl, Stefan, Löfblom, John, Orlova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881397/
https://www.ncbi.nlm.nih.gov/pubmed/31776413
http://dx.doi.org/10.1038/s41598-019-54149-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881397/
https://www.ncbi.nlm.nih.gov/pubmed/31776413
http://dx.doi.org/10.1038/s41598-019-54149-3

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