Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

Epithelial tumor progression often involves epithelial-mesenchymal transition (EMT). We report that increased intracellular levels of thyroid hormone (TH) promote the EMT and malignant evolution of squamous cell carcinoma (SCC) cells. TH induces the EMT by transcriptionally up-regulating ZEB-1, mese...

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Detalles Bibliográficos
Autores principales: Miro, Caterina, Di Cicco, Emery, Ambrosio, Raffaele, Mancino, Giuseppina, Di Girolamo, Daniela, Cicatiello, Annunziata Gaetana, Sagliocchi, Serena, Nappi, Annarita, De Stefano, Maria Angela, Luongo, Cristina, Antonini, Dario, Visconte, Feliciano, Varricchio, Silvia, Ilardi, Gennaro, Del Vecchio, Luigi, Staibano, Stefania, Boelen, Anita, Blanpain, Cedric, Missero, Caterina, Salvatore, Domenico, Dentice, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881453/
https://www.ncbi.nlm.nih.gov/pubmed/31776338
http://dx.doi.org/10.1038/s41467-019-13140-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881453/
https://www.ncbi.nlm.nih.gov/pubmed/31776338
http://dx.doi.org/10.1038/s41467-019-13140-2

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