Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma

Lung adenocarcinoma (LAD) is a human malignancy successfully treated with the tyrosine kinase inhibitor (TKI) gefitinib; however, the enrichment of therapy resistant cancer stem cells (CSCs) in such patients is assumed to be a source of treatment failure. Evaluation of LAD cell populations treated w...

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Detalles Bibliográficos
Autores principales: Sun, Jiangtao, Li, Guifang, Liu, Yiwen, Ma, Mingyang, Song, Kaifang, Li, Huaxu, Zhu, Daxing, Tang, XiaoJun, Kong, Jinyu, Yuan, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881627/
https://www.ncbi.nlm.nih.gov/pubmed/31765940
http://dx.doi.org/10.1016/j.neo.2019.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881627/
https://www.ncbi.nlm.nih.gov/pubmed/31765940
http://dx.doi.org/10.1016/j.neo.2019.10.006

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