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2D (2 Dimensional) TEQR design for Determining the optimal Dose for safety and efficacy
Designs, such as the Eff-Tox, OBD (optimal biological dose), STEIN (simple efficacy toxicity interval), and TEPI (toxicity efficacy probability interval) designs, have been proposed to determine the optimal dose of a new oncology drug using both efficacy and toxicity. The goal of these designs is to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881644/ https://www.ncbi.nlm.nih.gov/pubmed/31799471 http://dx.doi.org/10.1016/j.conctc.2019.100461 |