Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known. ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, asparagine synthetase (ASNS), replenishes asparagine. A...

Descripción completa

Detalles Bibliográficos
Autores principales: Mukherjee, Amitava, Ahmed, Nayyar, Rose, Fateema T., Ahmad, Abraheem N., Javed, Tanveer A., Wen, Li, Bottino, Rita, Xiao, Xiangwei, Kilberg, Michael S., Husain, Sohail Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881672/
https://www.ncbi.nlm.nih.gov/pubmed/31421261
http://dx.doi.org/10.1016/j.jcmgh.2019.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881672/
https://www.ncbi.nlm.nih.gov/pubmed/31421261
http://dx.doi.org/10.1016/j.jcmgh.2019.08.003

Ejemplares similares