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Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known. ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, asparagine synthetase (ASNS), replenishes asparagine. A...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Amitava, Ahmed, Nayyar, Rose, Fateema T., Ahmad, Abraheem N., Javed, Tanveer A., Wen, Li, Bottino, Rita, Xiao, Xiangwei, Kilberg, Michael S., Husain, Sohail Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881672/ https://www.ncbi.nlm.nih.gov/pubmed/31421261 http://dx.doi.org/10.1016/j.jcmgh.2019.08.003

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