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Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting

OBJECTIVE: Fasting results in major metabolic changes including a switch from glycogenolysis to gluconeogenesis to maintain glucose homeostasis. However, the relationship between the length of fasting and the relative contribution of gluconeogenic substrates remains unclear. We investigated the rela...

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Detalles Bibliográficos
Autores principales: Wang, Yujue, Kwon, Hyokjoon, Su, Xiaoyang, Wondisford, Fredric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881678/
https://www.ncbi.nlm.nih.gov/pubmed/31918920
http://dx.doi.org/10.1016/j.molmet.2019.11.005