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Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice

PURPOSE: Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and disability and imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays a role in the progressive damage following SCI and evaluate the potential for devel...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Zhang, Lu, Ndong, Jean De La Croix, Hettinghouse, Aubryanna, Sun, Guodong, Chen, Changhong, Zhang, Chen, Liu, Ronghan, Liu, Chuan-ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882111/
https://www.ncbi.nlm.nih.gov/pubmed/31775776
http://dx.doi.org/10.1186/s12974-019-1630-1