Cargando…

Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice

PURPOSE: Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and disability and imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays a role in the progressive damage following SCI and evaluate the potential for devel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Chao, Zhang, Lu, Ndong, Jean De La Croix, Hettinghouse, Aubryanna, Sun, Guodong, Chen, Changhong, Zhang, Chen, Liu, Ronghan, Liu, Chuan-ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882111/ https://www.ncbi.nlm.nih.gov/pubmed/31775776 http://dx.doi.org/10.1186/s12974-019-1630-1

Ejemplares similares

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
por: Jian, Jinlong, et al.
Publicado: (2017)

Cytosolic Phospholipase A2 Is Required for Fexofenadine’s Therapeutic Effects against Inflammatory Bowel Disease in Mice
por: Zhao, Xiangli, et al.
Publicado: (2021)

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
por: Wei, Jian-lu, et al.
Publicado: (2017)

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
por: Jian, Jinlong, et al.
Publicado: (2016)

Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models
por: Hettinghouse, Aubryanna, et al.
Publicado: (2018)

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
por: Martens, Lauren Herl, et al.
Publicado: (2022)

Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction
por: Sasaki, Takahiro, et al.
Publicado: (2023)

Progranulin in frontotemporal lobar degeneration and neuroinflammation
por: Ahmed, Zeshan, et al.
Publicado: (2007)

Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood–Spinal Cord Barrier Disruption in Spinal Cord Injury
por: Feng, Zhou, et al.
Publicado: (2021)

Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway
por: Wei, Jianlu, et al.
Publicado: (2020)

Abnormal angiogenesis of placenta in progranulin-deficient mice
por: Xu, Bairuo, et al.
Publicado: (2020)

Elucidating the Potential Mechanisms Underlying Distraction Spinal Cord Injury-Associated Neuroinflammation and Apoptosis
por: Han, Bo, et al.
Publicado: (2022)

Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases
por: Chen, Yue-hong, et al.
Publicado: (2022)

RNA-Seq analysis of interferon inducible p204-mediated network in anti-tumor immunity
por: Jian, Jinlong, et al.
Publicado: (2018)

Ferulic acid improves motor function induced by spinal cord injury in rats via inhibiting neuroinflammation and apoptosis
por: Jiang, Xi, et al.
Publicado: (2021)

Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
por: Li, Xinyu, et al.
Publicado: (2020)

Sepsis-associated neuroinflammation in the spinal cord
por: Hirotsu, Akiko, et al.
Publicado: (2022)

Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation
por: Du, Huan, et al.
Publicado: (2023)

p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice
por: Yi, Young-Su, et al.
Publicado: (2018)

Progranulin deficiency in Iba-1(+) myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
por: Takahashi, Kei, et al.
Publicado: (2021)

Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord
por: Li, Ting, et al.
Publicado: (2023)

Complement C6 deficiency exacerbates pathophysiology after spinal cord injury
por: Su, Diane, et al.
Publicado: (2020)

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord
por: Liu, Ming, et al.
Publicado: (2014)

Progranulin deficiency leads to reduced glucocerebrosidase activity
por: Zhou, Xiaolai, et al.
Publicado: (2019)

Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury
por: Xiao, Shining, et al.
Publicado: (2023)

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation
por: Grin’kina, Natalia M., et al.
Publicado: (2012)

Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice
por: Zhao, Xiangli, et al.
Publicado: (2022)

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation
por: Petkau, Terri L., et al.
Publicado: (2017)

High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury
por: Zhang, Wenqian, et al.
Publicado: (2021)

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
por: Zhang, Jiasheng, et al.
Publicado: (2020)

Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
por: Wang, Jing, et al.
Publicado: (2022)

Experimental Pulmonary Hypertension Is Associated With Neuroinflammation in the Spinal Cord
por: Vaillancourt, Mylene, et al.
Publicado: (2019)

Inflammation & apoptosis in spinal cord injury
por: Zhang, Ning, et al.
Publicado: (2012)

Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction
por: Fu, Wenyu, et al.
Publicado: (2020)

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
por: Evers, Bret M., et al.
Publicado: (2017)

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus
por: Hardt, Stefanie, et al.
Publicado: (2018)

Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice
por: Schmitz, Katja, et al.
Publicado: (2019)

Increased Fat Taste Preference in Progranulin-Deficient Mice
por: Schumann, Lana, et al.
Publicado: (2021)

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
por: Pang, Qi-Ming, et al.
Publicado: (2021)

Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
por: Wu, Xue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g427nk57nkhap80lu101me5llv