Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

BACKGROUND: Mutations in genes associated with homologous recombination (HR) increase an individual’s risk of developing triple-negative breast cancer (TNBC). Although known for their role in repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Essential t...

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Detalles Bibliográficos
Autores principales: Pearson, Scott J., Elswood, Jessica, Barhoumi, Rola, Ming-Whitfield, Brittini, Rijnkels, Monique, Porter, Weston W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882179/
https://www.ncbi.nlm.nih.gov/pubmed/31775907
http://dx.doi.org/10.1186/s13058-019-1207-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882179/
https://www.ncbi.nlm.nih.gov/pubmed/31775907
http://dx.doi.org/10.1186/s13058-019-1207-z

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