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Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress
BACKGROUND: Mutations in genes associated with homologous recombination (HR) increase an individual’s risk of developing triple-negative breast cancer (TNBC). Although known for their role in repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Essential t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882179/ https://www.ncbi.nlm.nih.gov/pubmed/31775907 http://dx.doi.org/10.1186/s13058-019-1207-z |