One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults

Human (h) and mouse (m) embryonic stem (ES) cells need specific amino acids to proliferate. mES cells require threonine (Thr) metabolism for epigenetic histone modifications. Thr is converted to glycine and acetyl CoA, and the glycine is metabolized specifically to regulate trimethylation of lysine...

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Detalles Bibliográficos
Autores principales: Van Winkle, Lon J., Ryznar, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882271/
https://www.ncbi.nlm.nih.gov/pubmed/31824950
http://dx.doi.org/10.3389/fcell.2019.00300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882271/
https://www.ncbi.nlm.nih.gov/pubmed/31824950
http://dx.doi.org/10.3389/fcell.2019.00300

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