PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity

BACKGROUND: The pathogenesis of chemotherapy-induced neuropathy, a dose-dependent adverse effect of cisplatin, involves mitochondrial dysfunction. PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy removes damaged mitochondria under various pathological conditions. The objective of thi...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Liu, Qingzhen, Li, Yongle, Li, Caijuan, Zhu, Yunhe, Xia, Fan, Xu, Shiqin, Li, Weiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882296/
https://www.ncbi.nlm.nih.gov/pubmed/31748499
http://dx.doi.org/10.12659/MSM.918536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882296/
https://www.ncbi.nlm.nih.gov/pubmed/31748499
http://dx.doi.org/10.12659/MSM.918536

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